It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.
This website no longer supports Internet Explorer due to privacy and security reasons. To avoid errors, please open https://salus.sa.gov.au in Chrome, Safari, Firefox or Edge.
LFTs – INR, ALT, ALP, AST, GGT, bilirubin, albumin and pattern of change
SIGNS AND SYMPTOMS OF LIVER DISEASE – eg. ascites, oesophageal varices, jaundice, encephalopathy
CAUSE OF LIVER IMPAIRMENT – chronic (eg. alcoholic liver disease) or acute (eg. drug induced)
CREATININE – ensure no hepato-renal syndrome/renal impairment if using medications which are renally cleared
PHARMACOKINETICS – favourable characteristics in liver impairment are renal excretion, short half-life, low protein binding, no high first-pass metabolism, no active metabolites and no enterohepatic recirculation
PHARMACODYNAMICS– avoid or use with caution any medications with side effects which might worsen signs/symptoms of liver disease (eg. blood thinning, oesophageal reflux, fluid retention, sedation/CNS activity, constipation, hepatotoxic)
HEPATOTOXICITY– consider current drug causes, hold/suspend any non-essential medications which may cause severe/fatal hepatotoxicity