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SA Pharmacy Medicines Information Service

Parenteral Compatibility/Stability

Consider…

CONCENTRATIONS – compatibility is often concentration dependent

DILUENT– medication must be compatible with diluent

LINES AND LUMENS –  peripheral or central, number of lumens in central line

HOW WILL THE MEDICATIONS COME INTO CONTACT – Y-site, admixture, syringe

ADMINISTRATION RATES – indicates duration of contact

CONTAINER  PVC, polyethylene, polyurethane, polyolefin

OTHER PARENTERAL MEDICATIONS/ FLUIDS – provides alternative compatibility options

pH – medications unlikely to be compatible if there is a large difference in pH

SAFETY –  will administration change the rate of the medication already running. Is this safe/appropriate?

ALTERNATIVE – route of administration (eg rectal)

General Resources ​

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Specialised Resources

               

   

 

Palliative Care/Syringe Driver Compatibility

 

If compatibility uncertain and concurrent administration unavoidable, alert prescriber and monitor for signs of physical incompatibility (precipitation, cloudiness, colour change) – the event of which requires cessation of the infusion.

 

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